Rapid air evacuation of wounded from combat zones is questioned

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Department of Defense civilians and active-duty servicemembers attend a traumatic brain injury open house in March 2014 at Tripler Army Medical Center located in Honolulu. according to a new study conducted by the University of Maryland School of Medicine, rapid air evacuation has the potential to cause more damage to patients suffering from traumatic brain injury.  Christopher Hubenthal/U.S. Air Force
Department of Defense civilians and active-duty servicemembers attend a traumatic brain injury open house in March 2014 at Tripler Army Medical Center located in Honolulu. according to a new study conducted by the University of Maryland School of Medicine, rapid air evacuation has the potential to cause more damage to patients suffering from traumatic brain injury. Christopher Hubenthal/U.S. Air Force

Rapid air evacuation of wounded from combat zones is questioned

by: Thomas Gibbons-Neff | .
The Washington Post | .
published: December 01, 2015

Over the past 15 years, the United States has flown its wounded troops out of combat zones to hospitals around the globe. The logic: Get those hurt in places where medical supplies are limited to places where they are not. The fastest way to do this? By air.

Yet according to a new, first-of-its-kind study conducted by the University of Maryland School of Medicine, rapid air evacuation has the potential to cause more damage to those patients suffering from an extremely prevalent battlefield affliction — traumatic brain injury.

More than 330,000 U.S. servicemembers have suffered from traumatic brain injuries, one of the leading causes of death and disability for those returning from Iraq and Afghanistan, according to the study published Monday in the Journal of Neurotrauma.

The study, funded by a $2.5 million U.S. Air Force grant, was helmed by Alan I. Faden, a professor of anesthesiology at the University of Maryland School of Medicine.

The study used rats that were given traumatic brain injuries and then placed in chambers that would simulate air pressure in a military transport aircraft, such as a C-17. A pressurized cabin in a military transport aircraft at cruising altitude roughly equates to being in the open air 9,000 feet above sea level, according to Faden, while a civilian airliner feels like being around 6,000 feet.

"What we found is that they were materially worse at the end," Faden said. "They were worse in behavioral terms, and when we actually looked at the brains they lost cells in the critical hippocampal regions, the place where one makes memories."

The tests also found that the inflammation of the brain that typically occurs after a head injury was "substantially enhanced" after the rats were subjected to the pressure changes.

Faden used what's known as the "fluid percussion model" to create the head injuries in the rats. According to Faden, the model is common for examining the effects of head injuries on rodents and the potential ramifications for humans. While some scientific tests on rodents do not carry over to humans, they have been mostly accurate when it comes to examining certain effects of head injuries, Faden added.

Typically after a battlefield injury, U.S. troops have been stabilized at a field hospital in either Iraq or Afghanistan before being flown to Landstuhl, Germany. They usually receive additional treatment there before being sent back to the United States.

In follow-on tests, Faden put the injured rats through two sessions of pressurization two days apart, simulating what servicemembers might go through if they were flying from Afghanistan to Germany and then on to the United States. Faden said he found that repeated exposures to pressurized cabins with a mild injury compounded the effects to mimic a larger head injury.

The study also looked at the results of air transport in the days following an injury. According to Faden, there was added inflammation to the brain after transport seven days post-injury.

In the majority of the tests, the rats were given oxygen to ensure the oxygen levels in their blood were normal, while in some tests — to mimic real-world medical treatment — the rats were given 100 percent supplemental oxygen to simulate the treatment often prescribed to patients in transport.

"What we showed is that if you give 100 percent supplemental oxygen in this condition of air evacuation pressure, it was worse than just giving enough oxygen to normalize the oxygen tension," Faden said.

To Faden, the study highlights the need to weigh the benefits of rapid air evacuation against keeping patients stabilized closer to the battlefield before airlifting them home.

"The major point of this is to rethink this issue," Faden said, adding that he hopes the Air Force will look at ways to better pressurize aircraft or find other methods to lessen the effects of pressurization.